Chemical Pathology

Chemical Pathology is another discipline in the field of Pathology which deals with the entire range of disease. It encompasses detecting changes in a wide range of substances in blood and body fluids (electrolytes, enzymes and proteins) in association with many diseases. In addition, it involves detecting and measuring tumour (cancer) markers, hormones, poisons and both therapeutic and illicit drugs. For example Chemical Pathologists are involved in assessing levels of iron in the blood, measuring the levels of enzymes that are released into the blood after a heart attack to help in the diagnosis, and in the measurement of certain proteins produced by cancers to monitor the response to their treatment.

As with the other clinical pathology specialities, the largest part of a Chemical Pathologist’s day is typically spent in clinical liaison. This involves advising clinicians about the appropriate tests for the investigation of a particular clinical problem, the interpretation of results and follow-up, and the effect of interferences eg by therapeutic drugs on test results. The working day also has a large component devoted to the validation and interpretation of test results, particularly for unusually abnormal results or more uncommon and highly specialised tests.

Evaluation of new technology and the development of new tests is an ongoing process in Chemical Pathology. This applies particularly to areas that are now opening up, such as the use of molecular biology techniques in diagnostic tests. Specialist areas of interest include such topics as inherited metabolic diseases, trace metals and environmental monitoring, drugs of abuse, and nutrition.

Alcohol / Ammonia

Aqueous BSA – 3mL vials to assess alcohol ammonia measurements

Frequency / Number of samples

12 surveys per year / 2 samples per survey

Tests

Ethanol, Ammonia


Product details last updated on September 13, 2018

B-Natriuretic Peptide (BNP)

Lyophilised Serum – 0.5mL vials to assess B-type Natriuretic Peptide assays.

Note: May not be suitable for some POC analysers (e.g. h232)

Frequency / Number of samples

12 surveys per year / 2 samples per survey

Tests

B-type Natriuretic Peptide (BNP), N-terminal Prohormone B-type Natriuretic Peptide (NT-pro BNP)


Product details last updated on August 9, 2019

Bile Acids

Lyophilised Serum – 2mL vials to assess bile acids measurements

Frequency / Number of samples

12 surveys per year / 2 samples per survey

Tests

Total Bile Acids

Blood Gases

Aqueous Bovine Albumin Buffered Matrix – 2.5mL ampoules to assess related methods available on blood gas analysers.

Note: Abbott i-STAT and Siemens epoc devices requiring a haematocrit should enrol in the PoCT Blood and Gases Program.

Frequency / Number of samples

12 surveys per year / 2 samples per survey

Tests

pH, Potassium, Ionised Calcium, pCO2, Chloride, Urea, pO2, Glucose, Creatinine, Sodium, Lactate


Product details last updated on August 9, 2019

Blood gases: CO-Oximetry

Lyophilised Bovine Haemoglobin – 0.5mL vials to assess performance for CO-Oximetry assay.

Note: This program is not suitable for Abbott i-STAT devices.

Frequency / Number of samples

12 surveys per year / 2 samples per survey

Tests

Haemoglobin, Oxyhaemoglobin, Carboxyhaemoglobin, Methaemoglobin


Product details last updated on August 9, 2019

C-Reactive Protein (CRP)

Serum – 0.5 mL vials to assess CRP from low to high levels

Frequency / Number of samples

12 surveys / 2 samples per survey

Tests

C-Reactive Protein


Product details last updated on August 9, 2019

Compact Serum Chemistry (for Overseas Participants only)

Lyophilised Serum and Matching Diluent – 5mL vials to assess performance across a range of routine chemical pathology assays including therapeutic drugs and endocrine.

This program is ONLY available to participants outside Australia and New Zealand.

Frequency / Number of samples

6 surveys per year / 2 samples per survey

Tests

Albumin Enzymes Endocrine
Bicarbonate ALT Cortisol
Bilirubin – Total Alkaline Phosphatase Thyroxine
Bilirubin – Conjugated Amylase Free T4
Calcium AST TSH
Chloride Cholinesterase Total T3
Creatinine Creatine Kinase Free T3
Fructosamine CK-MB hCG (quantitative)
Glucose GGT hCG (qualitative)
Lactate Lactate Dehydrogenase Drugs
Lithium Lipase Carbamazepine
Magnesium Iron Digoxin
Osmolality TIBC Paracetamol
Phosphate (Inorganic) Transferrin Phenobarbitone
Potassium Ferritin Phenytoin
Protein (Total) Lipids Salicylate
Sodium Cholesterol Theophylline
Urate Triglyceride Valproate
Urea HDL Cholesterol Gentamicin
Troponin I (quantitative) Vancomycin

Troponin T (quantitative)

Troponin T (semi-qualitative) Roche Cardiac reader only

Troponin T (qualitative)

Note. Troponin T (semi-qualitative) on Roche Instruments. Participants using the Roche Cardiac Reader should enrol in the General Serum Chemistry Program. Participants using Roche Cobas h232 instruments should enrol in the PoCT Troponin Program. This is due to the different cut-offs, standardisation and units for these 2 instruments.


Product details last updated on August 13, 2019

Condensed Point of Care General Chemistry (for Australian and NZ Participants only)

Lyphophilised serum and Matching Diluent – 5mL vials to assess performance of a range of chemistry and endocrine assays.

This program is ONLY available to participants in Australia and New Zealand.

Frequency / Number of samples

12 surveys per year / 2 samples per survey

Tests

AST

Bicarbonate

Bilirubin – Total

Bilirubin – Conjugated

Calcium

Chloride

Cholesterol

Creatine Kinase

GGT

Glucose

HDL Cholesterol

hCG (qualitative)

Lactate

Lactate Dehydrogenase

Lipase

 

Lithium

Magnesium

Phosphate (Inorganic)

Potassium

Protein (Total)

Sodium

Triglyceride

Urate

Urea

Troponin I (quantitative)

Troponin T (quantitative)

Troponin T (semi-quantitative, Roche Cardiac reader only)

Troponin T Qualitative

 


Product details last updated on August 29, 2019

Condensed Point-of-Care Testing: Blood Gases

Aqueous Bovine Albumin Buffered Matrix – 2.5mL ampoules designed to assess related methods available on I-Stat type analysers, not suited to Radiometer and Siemens type devices

Frequency / Number of samples

6 surveys per year / 2 samples per survey

Tests

pH, Sodium, Glucose, Ionised Calcium, pCO2, Potassium, Haemoglobin, Haematocrit, , pO2, Chloride, Lactate, Creatinine, TCO2, Urea

Note: Suitable for devices such as the Abbott i-STAT and Siemens epoc devices.


Product details last updated on August 9, 2019

Condensed Point-of-Care Testing: Troponin and HCG

Lyophilised Plasma – 1mL vials for assessment of Troponin Tand I and Total HCG on PoC devices

Frequency / Number of samples

6 surveys per year / 2 samples per survey

Tests

Troponin I, Troponin T (semi-quantitative e.g. h232), Total HCG


Product details last updated on August 9, 2019

Condensed Serum Chemistry (for Overseas Participants only)

Lyophilised Serum and Matching Diluent – 5mL vials to assess performance across a range of routine chemical pathology assays including therapeutic drugs and endocrine.

This program is ONLY available to participants outside Australia and New Zealand.

Frequency / Number of samples

12 surveys per year / 2 samples per survey

Tests

Albumin Enzymes Endocrine
Bicarbonate ALT Cortisol
Bilirubin – Total Alkaline Phosphatase Thyroxine
Bilirubin – Conjugated Amylase Free T4
Calcium AST TSH
Chloride Cholinesterase Total T3
Creatinine Creatine Kinase Free T3
Fructosamine CK-MB hCG (quantitative)
Glucose GGT hCG (qualitative)
Lactate Lactate Dehydrogenase Drugs
Lithium Lipase Carbamazepine
Magnesium Iron Digoxin
Osmolality TIBC Paracetamol
Phosphate (Inorganic) Transferrin Phenobarbitone
Potassium Ferritin Phenytoin
Protein (Total) Lipids Salicylate
Sodium Cholesterol Theophylline
Urate Triglyceride Valproate
Urea HDL Cholesterol Gentamicin
Troponin I (quantitative) Vancomycin

Troponin T (quantitative)

Troponin T (semi-qualitative) Roche Cardiac reader only

Troponin T (qualitative)

Note. Troponin T (semi-qualitative) on Roche Instruments. Participants using the Roche Cardiac Reader should enrol in the General Serum Chemistry Program. Participants using Roche Cobas h232 instruments should enrol in the PoCT Troponin Program. This is due to the different cut-offs, standardisation and units for these 2 instruments.


Product details last updated on August 13, 2019

CSF Chemistry

Lyophilised CSF – 2mL vials to assess common chemistry assays in a related CSF matrix

Frequency / Number of samples

12 surveys per year / 2 samples per survey

Tests

Total Protein, Immunoglobulin G, Glucose, Lactate, Albumin,

Xanthochromia Screen – Haemoglobin (absorbance & qualitative),

Xanthochromia Screen – Bilirubin (absorbance, concentration & qualitative)


Product details last updated on August 9, 2019