Acute lymphoid leukaemia (ALL) Gene Testing (Pilot)

This module qualitatively assesses laboratory performance in the detection of variants in acute lymphoid leukaemia.

Frequency / Number of samples

1 survey / 1 sample per survey

Tests

Molecular/Acute lymphoid leukaemia

AdenovirusQCMD Programme Code: ADVDNA18QCMD Catalogue Number: QAV054133_1 (1 Challenge)

Analysis Type: Qual & Quant.
Shipping Conditions: Dry-ice

Frequency / Number of samples

QCMD Catalogue Number: QAV054133_1
1 Challenge
8-12 Panel Members per Challenge

AdenovirusQCMD Programme Code: ADVDNA18QCMD Catalogue Number: QAV054133_2 (2 Challenges)

Analysis Type: Qual & Quant.
Shipping Conditions: Dry-ice

Frequency / Number of samples

QCMD Catalogue Number: QAV054133_2
2 Challenges
4-6 Panel Members per Challenge

Alcohol / Ammonia

Aqueous BSA – 3mL vials to assess alcohol ammonia measurements

Frequency / Number of samples

12 surveys per year / 2 samples per survey

Tests

Ethanol, Ammonia

ALK Translocation in NSCLC

This module qualitatively assesses laboratory performance in the detection, reporting and interpretation of Anaplastic Lymphoma Kinase (ALK) gene rearrangement in non-small cell lung cancer (NSCLC) using either fluorescence in-situ hybridisation (FISH), immunohistochemistry (IHC) or other routine molecular methods.

Frequency / Number of samples

1 survey / 3 samples per survey (Patient-derived FFPE tissue)

Tests

Molecular genetic analysis to determine ALK gene rearrangement status

Antenatal – Rubella serology

Clinical material (Liquid Serum / Plasma – 0.7 mL) provided to assess the detection of Rubella using serological markers

Frequency / Number of samples

4 surveys / 2 samples per survey

Tests

Rubella Total Antibody, Rubella IgG, Rubella IgM, Rubella Avidity, Rubella Interpretation

Antenatal – Syphilis serology

Clinical material provided (Liquid Serum / Plasma – 0.5 mL) to assess the detection of Syphilis using serological markers

Frequency / Number of samples

4 surveys / 2 samples per survey

Tests

Syphilis Total Antibody, Syphilis RPR, Syphilis Agglutination (TPHA/TPPA), Syphilis FTA-ab, Syphilis VDRL, Syphilis ICT, Syphilis IgG, Syphilis IgM, Syphilis Immunoblot, Syphilis Interpretation, Syphilis Total Ab EIA confirmatory

Anti-nuclear Antibodies

Serum – 500 μL provided to determine the presence of Anti-nuclear antibodies including pattern, titre and appropriate commentary.

Frequency / Number of samples

10 surveys / 2 samples per survey

Tests

Anti-Nuclear Antibodies pattern, Anti-Nuclear Antibodies titre

Anti-Saccharomyces cerevisiae Antibodies

Serum – 500 μL provided for the quantitation and qualitative assessment of Anti-Saccharomyces cerevisiae antibodies (IgG, IgA)

Frequency / Number of samples

6 surveys / 1 sample per survey

Tests

Anti-Saccharomyces cerevisiae IgA and IgG antibodies

Antiphospholipid Antibodies

Serum – 500 μL provided for quantitation and qualitative assessment of Anti-cardiolipin and Anti-Beta 2-Glycoprotein 1 antibodies (IgG, IgA and IgM)

Frequency / Number of samples

8 surveys / 1 sample per survey

Tests

Cardiolipin IgG, IgA and IgM antibodies, β2 Glycoprotein 1 IgG, IgA and IgM antibodies

Apixaban (Anti Xa)

Lyophilised plasma – 1 mL provided to assess Apixaban (Anti Xa) measurements

Frequency / Number of samples

2 surveys / 2 samples per survey

Tests

Apixaban (Anti Xa)

Arrhythmias

DNA (in TE Buffer)

Frequency / Number of samples

1 survey / 3 samples per survey

Tests

As testing approaches are still not standardized and vary between laboratories, the exact list of genes to be tested is not specified.